Advances of researches on caspases in neurodegenerative diseases / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 438-442, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-234635
Biblioteca responsável:
WPRO
ABSTRACT
Acute and chronic neurodegenerative diseases are illnesses associated with high morbidity and mortality, and few or no effective options are available for their treatments. Many neurodegenerative diseases are included in them, for example, stroke, brain trauma, spinal cord injury, amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's disease, and Parkinson's disease. Given that central nervous system tissue has very limited, if any, regenerative capacity, it is of utmost importance to limit the damage caused by neuronal death. During the past decade, considerable progress has been made in understanding the process of cell death. In this article, we review the causes and mechanisms of neuronal-cell death, especially as it pertains to the caspases family of proteases associated with cell death. The results may be helpful to the experimental research and clinical application of neurodegenerative diseases.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Peptídeo Hidrolases
/
Fisiologia
/
Morte Celular
/
Apoptose
/
Doenças Neurodegenerativas
/
Caspases
/
Metabolismo
/
Neurônios
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2013
Tipo de documento:
Artigo