Familial pedigree analysis of Shen-yin deficiency syndrome in families with type 2 diabetes mellitus GU / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 600-603, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-234817
Biblioteca responsável:
WPRO
ABSTRACT
To analyse the familial aggregation and genetic predisposition of Shen-yin deficiency syndrome (SYDS) in families with diabetes mellitus type 2 (DM2). Methods One hundred and forty-one DM2 patients were collected from 32 family lines in Nanjin area, in which the probands were differentiated as DM2 with SYDS. On them, genetic analysis on the characteristics of SYDS was conducted using pedigree analysis, morbidity and heritability of the first-degree relatives of the probands were calculated, and the action of familial SYDS factor on the genesis of the syndrome was assessed by multiple factors regression analysis. Results The morbidity rate of SYDS in the first-degree relatives of the probands was 33.71%, and the heritability, calculated by Falconer formula, was 80.6%. The fitting result of regression analysis showed that familial factor played an important role in SYDS genesis (OR = 5.61, P = 0.001), but DM2 itself is not an independent risk factor for it. Conclusion DM2 with SYDS shows the tendency of familial aggregation and genetic predisposition, genetic factor is associated with the genesis of the syndrome. Pedigree research is a good method for exploring the relationship between syndrome and genetic factor.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linhagem
/
Deficiência da Energia Yin
/
Predisposição Genética para Doença
/
Diabetes Mellitus Tipo 2
/
Diagnóstico Diferencial
/
Genética
/
Medicina Tradicional Chinesa
Tipo de estudo:
Estudo diagnóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo