Study on drug release in vitro and rat intestinal absorption of resveratrol nanoliposomes / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1084-1088, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-235256
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the release feature of Res-nanoliposomes in vitro and clarify the difference in absorption of Res-nanoliposomes from varied intestinal segments and the absorptive mechanism in vivo.</p><p><b>METHOD</b>Dialytic method was used to determine resveratrol release rate of Res-nanoliposomes in vitro. An in situ rat perfusion method was used to investigate the intestinal absorption of Res-nanoliposomes.</p><p><b>RESULT</b>Resveratrol release from nanoliposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Compared with other intestinal segments, significantly high percentage of Res-nanoliposomes was absorbed in ileum (P < 0.001). The absorption rate constants (ka) of Res-nanoliposomes in intestine were not significantly different.</p><p><b>CONCLUSION</b>Res-nanoliposomes could sustain to release drug in vitro. The absorption was a first-order process with the passive diffusion mechanism. The Res-nanoliposomes could promote the absorption of Res in rat small intestine.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Plantas Medicinais
/
Estilbenos
/
Farmacocinética
/
Química
/
Administração Oral
/
Ratos Wistar
/
Preparações de Ação Retardada
/
Fallopia japonica
/
Composição de Medicamentos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo