Improved methods for monitoring sleep state and respiratory rhythm in freely moving rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 27-30, 2014.
Article
em Zh
| WPRIM
| ID: wpr-236395
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To improve the method for monitoring sleep state and respiratory rhythm of SD rats, providing a solution for rats' chewing on the wires, signal loss and instability problems in the animal model of sleep apnea syndrome (SAS).</p><p><b>METHODS</b>We improved monitoring electrodes of both electrocorticogram (ECoG) and electromyogram (EMG), signal circuit and animal operation.</p><p><b>RESULTS</b>Operation time was shortened and wound exposure time was reduced, which made it easier for postoperative recovery. The ECoG and EMG signals were more stable with sharp image, and signal circuit lines had better conductivity and material durability, achieving continuous monitoring for a long time and high success rate. We could precisely distinguish the sleep wake state and the sleep apnea events in rats according to these signals.</p><p><b>CONCLUSION</b>The improved method is more reliable and practical to test the small animal model of SAS, and is more easily to operate and the signals are more stable.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Respiração
/
Sono
/
Síndromes da Apneia do Sono
/
Modelos Animais
/
Diagnóstico
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Eletroencefalografia
/
Eletromiografia
/
Métodos
/
Monitorização Fisiológica
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2014
Tipo de documento:
Article