Mutation of tet2 gene and malignant blood disease / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1096-1100, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-237587
Biblioteca responsável:
WPRO
ABSTRACT
Tet2 (the 2nd member of tet oncogene family) is a newly discovered antioncogene on the chromosome 4q24 of the patient with malignant myeloma, which has a potential for functional deletion. Recent studies demonstrated that tet2 mutation was found in polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis, systematic mastocytosis (SM), and myelodysplastic syndrome (MDS). However, a great number of perspective researches are still needed for exploring the role of tet2 in the pathogenesis of malignant blood diseases. In this review, the relation of tet2 mutation with myeloproliferative neoplasm, systemic mastocytosis, myelodysplastic syndrome, acute myeloid leukemia and other malignant blood diseases are summarized.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndromes Mielodisplásicas
/
Proteínas Proto-Oncogênicas
/
Proteínas de Ligação a DNA
/
Genética
/
Doenças Hematológicas
/
Mutação
/
Transtornos Mieloproliferativos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2010
Tipo de documento:
Artigo