Beneficial Effect of Efonidipine, an L- and T-Type Dual Calcium Channel Blocker, on Heart Rate and Blood Pressure in Patients With Mild-to-Moderate Essential Hypertension
Korean Circulation Journal
; : 514-519, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-23761
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Efonidipine hydrochloride, an L- and T-type dual calcium channel blocker, is suggested to have a heart rate (HR)-slowing action in addition to a blood pressure (BP)-lowering effect. The aim of this study was to determine the effect of efonidipine on HR and BP in patients with mild-to-moderate hypertension. SUBJECTS ANDMETHODS:
In a multi-center, prospective, open-labeled, single-armed study, we enrolled 53 patients who had mild-to-moderate hypertension {sitting diastolic BP (SiDBP) 90-110 mmHg}. After a 2-week washout, eligible patients were treated with efonidipine (40 mg once daily for 12 weeks). The primary end point was the change in HR from baseline to week 12. The secondary end-point included the change in trough sitting BP and 24-hour mean BP between baseline and week 12. Laboratory and clinical adverse events were monitored at each study visit (4, 8, and 12 weeks).RESULTS:
Fifty-two patients were included in the intention-to-treat analysis. After 12 weeks of treatment with efonidipine, the resting HR decreased significantly from baseline to week 12 {from 81.5+/-5.3 to 71.8+/-9.9 beats/minute (difference, -9.9+/-9.0 beats/minute), p<0.0001}. The trough BP {sitting systolic blood pressure (SiSBP) and SiDBP} and 24-hour mean BP also decreased significantly (SiSBP from 144.6+/-8.2 to 132.9+/-13.5 mmHg, p<0.0001; SiDBP from 96.9+/-5.4 to 88.3+/-8.6 mmHg, p<0.0001, 24-hour mean systolic BP from 140.4+/-13.5 to 133.8+/-11.6 mmHg, p<0.0001; 24-hour mean diastolic BP from 91.7+/-8.7 to 87.5+/-9.5 mmHg, p<0.0001).CONCLUSION:
Efonidipine was effective in controlling both HR and BP in patients with mild-to-moderate hypertension.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Compostos Organofosforados
/
Pressão Sanguínea
/
Di-Hidropiridinas
/
Bloqueadores dos Canais de Cálcio
/
Canais de Cálcio
/
Cálcio
/
Estudos Prospectivos
/
Coração
/
Frequência Cardíaca
/
Hipertensão
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2010
Tipo de documento:
Artigo