Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3709-3712, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-237744
Biblioteca responsável:
WPRO
ABSTRACT
To build the Dendrobium nobile -T2DM network, and elucidate the molecular mechanism of D. nobile to type 2 diabetes (T2DM). Collect the chemical composition of D. nobile and the targets on T2DM by retrieving database and documents, build the network of D. nobile to T2DM using the entity grammar systems inference rules. The molecular mechanism of D. nobile to T2DM includes (1) regulating lipid metabolism by lowering triglyceride; (2) reducing insulin resistance; (3) protecting islet cells; (4) promoting the glucose-dependent insulin tropic peptide (GIP) secretion; (5) inhibiting calcium channel. Under the guidance of network pharmacology, through entity grammar systems inference rules we elucidate the molecular mechanism of D. nobile to T2DM, and provide the basis for the further development of health care products based on D. nobile.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triglicerídeos
/
Resistência à Insulina
/
Medicamentos de Ervas Chinesas
/
Canais de Cálcio
/
Química
/
Bases de Dados Factuais
/
Ilhotas Pancreáticas
/
Dendrobium
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo