Control of demyelination for recovery of spinal cord injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 306-310, 2008.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-239829
Biblioteca responsável:
WPRO
ABSTRACT
Since loss of oligodendrocytes and consequent demyelination of spared axons severely impair the functional recovery of injured spinal cord, it is reasonably expected that the reduction of oligodendroglial death and enhanced remyelination of demyelinated axons will have a therapeutic potential to treat spinal cord injury. Amelioration of axonal myelination in the injured spinal cord is valuable for recovery of the neural function of incompletely injured patients. Here, this article presents an overview about the pathophysiology and mechanism of axonal demyelination in spinal cord injury and discusses its therapeutic significance in the treatment of spinal cord injury. Moreover, it further introduces the recent strategies to improve the axonal myeliantion to facilitate functional recovery of spinal cord injury.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Traumatismos da Medula Espinal
/
Terapêutica
/
Doenças Desmielinizantes
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2008
Tipo de documento:
Artigo