Biosynthesis-based production improvement and structure modification of erythromycin A / 生物工程学报
Chinese Journal of Biotechnology
; (12): 939-954, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-240574
Biblioteca responsável:
WPRO
ABSTRACT
Erythromycin A is a clinically important macrolide antibiotic with broad-spectrum activity. Its biosynthesis involves the formation of the 14-membered skeleton catalyzed by polyketide synthases, and the modification steps such as hydroxylation, glycosylation and methylation. Based on the understanding of the biosynthetic mechanism, it is reliable to genetically manipulate the erythromycin A-producing strain for production improvement and structure modification. In this paper, we reviewed the progress regarding erythromycin A in high-producing strain construction and chemical structure derivation, to provide insights for further development.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicosilação
/
Química
/
Eritromicina
/
Família Multigênica
/
Policetídeo Sintases
/
Hidroxilação
/
Metabolismo
/
Metilação
/
Antibacterianos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2015
Tipo de documento:
Artigo