Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis / 中华男科学杂志
National Journal of Andrology
; (12): 809-813, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-241251
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of male infertility with CAG repeat polymorphism of the androgen receptor (AR) gene by meta-analysis.</p><p><b>METHODS</b>We identified the case-control studies on the relationship of male infertility with CAG repeats of the AR gene by searching Medline/PubMed and CBM databases, and conducted meta-analysis on the data obtained with the RevMan 4.2 software.</p><p><b>RESULTS</b>Thirty-two eligible articles were selected in this study, including 3,153 idiopathic infertile men and 2,314 controls. The combined data statistics showed that all the infertile men had a significantly higher mean of CAG repeats than the controls (SMD = 0.27, 95% CI 0.17-0.37, P < 0.01). The specific SMD between the infertile patients and controls was 0.29, 95% CI 0.08-0.50 for the azoospermic men, 0.27, 95% CI 0.13-0.41 for the moderate oligozoospermic men, and 0.18, 95% CI 0.02-0.33 for the severe oligozoospermic cases. The results of sensitivity analyses were consistent with those mentioned above.</p><p><b>CONCLUSION</b>The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Receptores Androgênicos
/
Repetições de Trinucleotídeos
/
Genética
/
Infertilidade Masculina
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Revisão sistemática
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2009
Tipo de documento:
Artigo