Metabolic pathways of dipfluzine in rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 168-172, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-241353
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the metabolic pathways of dipfluzine in rats.</p><p><b>METHODS</b>After an oral dose of dipfluzine (80 mg x kg(-1)) to rats, urine was collected for 12 h. The metabolites of dipfluzine in urine were chromatographed and identified by LC/DAD/MS methods.</p><p><b>RESULTS</b>In the rat urine, there were 1-(4-fluorophenyl)-4-piperazinylbutanone and its glucuronide, 4-hydroxybenzophenone and its glucuronide, 4-fluoro-gamma-hydroxybenzenebutanoic acid and its glucuronide and sulfate, diphenylmethanol and its glucuronide, dipfluzine, and benzophenone.</p><p><b>CONCLUSION</b>In rats, dipfluzine was mainly metabolized in the pathways of N-desalkylation at 1- and 4-positions of piperazine ring. Some of metabolites were further conjugated with glucuronic acid and/or sulfuric acid.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Urina
/
Benzofenonas
/
Cromatografia Líquida
/
Cinarizina
/
Ratos Wistar
/
Glucuronídeos
/
Cromatografia Gasosa-Espectrometria de Massas
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Artigo