Prognostic value of baseline C-reactive protein levels in patients undergoing coronary revascularization / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1628-1632, 2010.
Article
em En
| WPRIM
| ID: wpr-241748
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>C-reactive protein (CRP) is a lowly expressed marker for inflammatory response. This study aimed to evaluate the prognostic value of baseline CRP levels in patients undergoing coronary revascularization in the context of modern medical treatment.</p><p><b>METHODS</b>This was a retrospective study in a single center. Four hundred and fourteen patients were enrolled, who underwent coronary revascularization and received adequate medication for secondary prevention of coronary heart disease. The study compared the follow-up clinical outcomes between high level CRP group (CRP > 5 mg/L) and low level one. The median follow-up time was 551 days.</p><p><b>RESULTS</b>Compared with low CRP group, the relative risk (RR) of the major adverse cardiovascular and cerebral events (MACCE) in high CRP group was 5.131 (95%CI: 1.864-14.123, P = 0.002). There were no significant differences in death, myocardial infarction and stroke during the follow-up between two groups, but a higher risk of re-revascularization was found in high CRP group (RR 6.008, 95%CI: 1.667-21.665, P = 0.006). Cox regression analysis showed that only CRP level could contribute to MACCE during the follow-up. MACCE-free rate was much lower in high CRP group (Kaplan-Meier log-rank P < 0.001).</p><p><b>CONCLUSION</b>In the context of modern medical treatment, the baseline level of CRP is an independent predictor for long-term prognosis in patients with coronary revascularization.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cirurgia Geral
/
Proteína C-Reativa
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Estudos Retrospectivos
/
Doença das Coronárias
/
Metabolismo
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Métodos
/
Revascularização Miocárdica
Tipo de estudo:
Etiology_studies
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Observational_studies
/
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2010
Tipo de documento:
Article