Expression of miR-224 in diffuse large B cell lymphoma and its clinical significance / 中华血液学杂志
Chinese Journal of Hematology
; (12): 619-622, 2014.
Article
em Zh
| WPRIM
| ID: wpr-242102
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of miR-224 in diffuse large B cell lymphoma (DLBCL) and its relationship with clinical pathological features and prognosis.</p><p><b>METHODS</b>Real-time PCR was used to detect the expression of miR-224 in 168 DLBCL and 25 normal lymphoid tissues.</p><p><b>RESULTS</b>The expression of miR-224 in DLBCL (0.97 ± 0.33) was significantly lower than that in normal lymphoid tissues (1.87 ± 0.43, P<0.05). There were no significant correlations between the miR-224 expression and age (P=0.434), gender (P=0.613) tumors stage (P=0.250), IPI (P=0.355) and lactate dehydrogenase (P=0.398). Using the median of miRNA-224 expression as threshold, we subdivided patients into low and high expression group. The five-year progression-free survival and overall survival were significantly lower in low expression group as compared to those in high expression group.</p><p><b>CONCLUSION</b>miR-224 expression may play an important role in the development and progression of DLBCL and could be prognostic significance.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Prognóstico
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Linfoma Difuso de Grandes Células B
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MicroRNAs
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Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Ano de publicação:
2014
Tipo de documento:
Article