Effect of cell culture conditions on antibody heterogeneity / 生物工程学报
Chinese Journal of Biotechnology
; (12): 1880-1886, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-242441
Biblioteca responsável:
WPRO
ABSTRACT
With the advantage of clear target and little side effect, antibody drug has attracted widely attention of worldwide pharmaceutical companies. However, large scale mammalian cell culture and antibody quality analysis are the bottlenecks of antibody drug industrialization in China. Especially due to the significant effect of cell culture conditions on antibody heterogeneity. Therefore, it is extremely urgent to optimize cell culture conditions to favor the demands of antibody drug development. This review summarized the most recent advances in the effect of cell culture conditions on antibody quality, followed by addressing the key issues that might be strategically important for domestic antibody drug development.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Controle de Qualidade
/
Heterogeneidade Genética
/
Técnicas de Cultura de Células
/
Estabilidade Proteica
/
Métodos
/
Anticorpos Monoclonais
/
Formação de Anticorpos
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2013
Tipo de documento:
Artigo