Predictive value of QT interval dynamicity for sudden death in patients with idiopathic dilated cardiomyopathy / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 1093-1097, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-244097
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the predictive value of QT interval dynamicity for sudden death in patients with idiopathic dilated cardiomyopathy (DCM).</p><p><b>METHODS</b>Fifty-five patients with DCM (DCM group) and 27 healthy subjects (Control group, Con) were enrolled. Investigations included history collection, clinical examination, echocardiography, electrocardiogram and 24 h ambulatory electrocardiogram. Following indexes were determined left ventricle end diastolic dimension (LVEDD), left ventricle ejection fraction (LVEF), QT dispersion (QTd), SDNN, the slope of QT/RR plots of the linear regression, ventricular premature beats (VPB) and non-sustained ventricular tachycardia (NSVT). Primary end point for patients with DCM was all cause death.</p><p><b>RESULTS</b>LVEDD, QTd, VPB/24 h, NSVT/24 h, QTe/RR slope and QTp/RR slope were significantly higher while LVEF and SDNN were significantly lower in DCM group than in Con group (all P < 0.05). LVEDD, LVEF, QTd, SDNN, QTe/RR slope and QTp/RR slope were significantly different among DCM sudden death group, DCM non sudden death group and Con group (P < 0.05). LVEF, SDNN, QTe/RR slope and QTp/RR slope were significantly different between DCM sudden death and non sudden death group (P < 0.05). LVEF, QTd, VPB/24 h, QTe/RR slope and QTp/RR slope were significantly different between DCM with NSVT and DCM without NSVT group (P < 0.05). The sudden death rate of DCM patients with QTe/RR slope ≥ 0.210 was significantly higher than DCM patients with QTe/RR slope < 0.210 (54.5% vs. 21.1%, P < 0.05). Sudden death rate of QTp/RR slope ≥ 0.190 was also higher than those < 0.190 (52.2% vs. 21.9%, P < 0.05). The sudden death rate of DCM patients with both LVEF ≤ 35% and NSVT+ was 62.5%. Combining QTe/RR ≥ 0.210 with NSVT+ or LVEF ≤ 35%, the sudden death rates were 62.5% or 66.7%. Combining QTp/RR ≥ 0.190 with NSVT+ or LVEF ≤ 35%, the sudden death rates were 66.7% or 61.5%. Combining QTe/RR ≥ 0.210 or QTp/RR ≥ 0.190 with NVST+ and LVEF ≤ 35%, the sudden death rates were 77.8% or 70.0%.</p><p><b>CONCLUSIONS</b>High QT/RR slope is a risk factor for sudden death of DCM patients. QT/RR slope is a useful predictor for sudden death in DCM patients either independently or combined with NSVT or LVEF.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
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ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
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Doença Cardiovascular
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Anomalias Congênitas e Cromossômicas
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Outras Doenças Circulatórias
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
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Síndrome do QT Longo
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Cardiomiopatia Dilatada
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Estudos de Casos e Controles
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Valor Preditivo dos Testes
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Fatores de Risco
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Eletrocardiografia Ambulatorial
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Morte Súbita Cardíaca
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Diagnóstico
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Frequência Cardíaca
Tipo de estudo:
Estudo diagnóstico
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Estudo de etiologia
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Adulto
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Idoso
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Idoso, 80 anos ou mais
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2010
Tipo de documento:
Artigo