Modification of the method for establishing myocardial infarction model in rats / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1291-1294, 2009.
Article
em Zh
| WPRIM
| ID: wpr-244641
Biblioteca responsável:
WPRO
ABSTRACT
This study was conducted to modify the method for establishing the model of myocardial infarction by ligation of the left anterior descending branch (LAD) of coronary artery in rats, and then observations on them were made with the use of electrocardiography, heart function exam and histomorphology. 30 adult male inbred strain Wistar rats were randomly divided into two groups: sham group (n = 5) and model group (n = 25). Each rat in the model group underwent a ligation of the left anterior descending branch. Subsequently, the two groups were compared by use of electrocardiography, heart function and histomorphology. The results have demonstrated that, after being improved, the ligation of the left anterior descending branch of coronary artery is a good method to establish the stable model of myocardial infarction. It can be applied to the research in mechanism and treatment of myocardial infarction.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cirurgia Geral
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Distribuição Aleatória
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Ratos Wistar
/
Vasos Coronários
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Modelos Animais de Doenças
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Ligadura
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Métodos
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Infarto do Miocárdio
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2009
Tipo de documento:
Article