Proliferating activity and differentiation between peripheral cells and central cells in ameloblastoma / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the proliferating activities and differentiation between peripheral cells and central cells in ameloblastoma.</p><p><b>METHODS</b>Expressions of proliferating cell nuclear antigen (PCNA), Ki-67, CK10&13 and CK19 were detected in 43 ameloblastoma (15 follicular, 20 plexiform and 8 acanthomatous) by SP immunohistochemical methods.</p><p><b>RESULTS</b>The PCNA labelling indices were significantly higher in peripheral cells (5.12% +/- 2.76%) of tumour nests or strands than in central cells (1.36% +/- 1.02%, P < 0.001). The peripheral cells of tumour nests or strands exhibited a significantly higher Ki-67 labelling index (3.63% +/- 1.80%) than central cells (1.26% +/- 0.96%, P < 0.001). The labelling indices between PCNA and Ki-67 showed a significant correlation (P < 0.01). The positive expressions of CK10&13 and CK19 were significantly higher in central cells than in peripheral cells (P < 0.01).</p><p><b>CONCLUSIONS</b>The peripheral zones of tumour nests or strands are regarded as proliferating areas; there exists a significantly different differentiation between central cells and peripheral cells.</p>