Clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation.</p><p><b>METHODS</b>275 patients with hepatitis B virus--related acute-on-chronic liver failure were investigated. The patients were divided into familial aggregation and non-familial aggregation group basis on their epidemiological features. Clinical data and biochemical indicators between the two groups were analyzed statistically.</p><p><b>RESULTS</b>93 of 275 patients (33.82%) case were family aggregation. There was no significant difference compared with chronic hepatitis B patients (38.3%). The mean age of the two groups was 45.98 and 43.61 years old, respectively (P > 0.05). The rates of liver cirrhosis in family aggregation group were significant higher than non-familial aggregation group (73.91% vs 58.24%, p < 0.05). Serum total (TBil) and prothrombin activities (PTA) were no significant difference between the two groups, but ALT level in familial aggregation group was much higher (407.80 U/L vs 256.45 U/L, P 0.05).</p><p><b>CONCLUSION</b>Familial aggregation were not related to acute-on-chronic liver failure in chronic HBV hepatitis patients. But the rate of liver cirrhosis were higher in patients with familial aggregation.</p>