Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 439-442, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-247463
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.</p><p><b>METHOD</b>The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated.</p><p><b>RESULT</b>The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release.</p><p><b>CONCLUSION</b>The coating pellets show the obviously sustained-release effects.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Química
/
Tecnologia Farmacêutica
/
Ácidos Cumáricos
/
Ligusticum
/
Preparações de Ação Retardada
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo