Consumption of mercury-contaminated rice induces oxidative stress and free radical aggravation in rats / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 84-89, 2007.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-249884
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the oxidative stress induced by consumption of mercury-contaminated rice in rats, and to assess the possible public health risk of mercury contamination in Wanshan mining area.</p><p><b>METHODS</b>Sprague Dawley rats were fed the mercury-contaminated rice produced from Wanshan area for 90 days. The antioxidant status and the free radicals in rat serum were evaluated.</p><p><b>RESULTS</b>High mercury accumulation in organs of rats fed the mercury-contaminated rice confirmed the server pollution of mercury in Wanshan mining area. The intensity of electron spin resonance (ESR) signal increased by 87.38% in rats fed the rice from Wanshan compared with that in the control rats fed the rice from Shanghai, suggesting that chronic dietary consumption of rice from mercury mining area could induce an aggravation of free radicals. Feeding the mercury-contaminated rice was associated with significant decreases in the antioxidant enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and concentration of serum nitric oxide (NO), but it had no effect on serum nitric oxide synthase (NOS) activity. Feeding the mercury-contaminated rice raised the level of serum malonyldialdehyde (MDA), indicating the occurrence of oxidative stress.</p><p><b>CONCLUSION</b>The long-term dietary consumption of mercury-contaminated rice induces the aggravation of free radicals and exerts oxidative stress.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oryza
/
Superóxido Dismutase
/
Sangue
/
Encéfalo
/
Farmacocinética
/
Contaminação de Alimentos
/
China
/
Ratos Sprague-Dawley
/
Estresse Oxidativo
/
Óxido Nítrico Sintase
Limite:
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2007
Tipo de documento:
Artigo