RP-HPLC determination of loganin in mouse plasma and its pharmacokinetics / 药学学报
Acta Pharmaceutica Sinica
; (12): 548-550, 2002.
Article
em Zh
| WPRIM
| ID: wpr-251104
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To develop a method for determination of loganin in mouse plasma by using high-performance liquid chromatography. The method was employed to study pharmacokinetics of loganin.</p><p><b>METHODS</b>An RP-C18 was used as the stationary phase. The mobile phase consisted of methanol-water (30:70), at the flow-rate of 0.8 mL.min-1. The UV absorbance detector was set at 240 nm. Plasma samples were treated with solid phase extraction.</p><p><b>RESULTS</b>The recovery of loganin in mouse plasma was 86.0%-91.5%. The calibration curve in plasma was linear over the range of 0.01-5.00 micrograms.mL-1. The limit of quantitation was 10 ng.mL-1. The RSDs of intra-day and inter-day (n = 5) were less than 15%. The pharmacokinetic parameters were Cmax = 6.8 micrograms.mL-1, Tmax = 30 min, T1/2 alpha = 26.1 min, T1/2 beta = 29.01 min.</p><p><b>CONCLUSION</b>The method is accurate, sensitive and suitable for pharmcokinetic study of loganin. The absorption and elimination of loganin were rapid after ig in mice.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sangue
/
Farmacocinética
/
Adjuvantes Imunológicos
/
Cromatografia Líquida de Alta Pressão
/
Área Sob a Curva
/
Iridoides
/
Métodos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2002
Tipo de documento:
Article