The type I insulin-like growth factor receptor highly expressed in clonal cells of myelodysplastic syndromes / 中华血液学杂志
Chinese Journal of Hematology
; (12): 744-747, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-251455
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To probe the expression level of insulin-like growth factor-I receptor (IGF-IR) in malignant clone cells of myelodysplastic syndromes (MDS).</p><p><b>METHOD</b>The combination of fluorescence in situ hybridization (FISH) and immunochemistry (alkaline phosphatase anti-alkaline phosphatase, APAAP) was used to detect the expression of IGF-IR in the bone marrow cells of 40 MDS patients with abnormal karyotypes.</p><p><b>RESULTS</b>The average IGF-IR expression level on the clone cells \[(84.5 ± 14.2)%\] from the MDS cases was markedly elevated compared to the corresponding level on normal cells \[(11.4 ± 12.1)%\]. And the percentages of malignant clone cells in all 40 MDS cases were significantly correlated with the relevant percentages of IGF-IR positive nucleated cells (r = 0.929, P < 0.01).</p><p><b>CONCLUSIONS</b>IGF-IR might be taken as a marker of clone cells in MDS for its trait to malignant proliferation.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Síndromes Mielodisplásicas
/
Células Clonais
/
Receptor IGF Tipo 1
/
Metabolismo
Limite:
Adolescente
/
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2011
Tipo de documento:
Artigo