Effectiveness of the AML-XH-99-M3 protocol for treatment of acute promyelocytic leukemia in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 329-332, 2008.
Article
em Zh
| WPRIM
| ID: wpr-252086
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effectiveness of AML-XH-99-M3 protocol for treatment of acute promyelocytic leukemia (APL) in children.</p><p><b>METHODS</b>Thirty-three children with APL received AML-XH-99-M3 protocol treatment. The event-free survival (EFS), disease-free survival (DFS), and overall survival (OS) were evaluated by the Kaplan-Meier medthod with SPSS13.0 software.</p><p><b>RESULTS</b>Thirty patients (90.9%) achieved a complete remission (CR) after one course of treatment. The total CR rate was 100%. Six patients (18.2%) relapsed in an average of 29.17 months (16-38 months). Two patients (6.1%) died. The 7-year EFS and DFS in the 30 patients were 73.4+/-9.4%. The overall survival rate was 91.2+/-6.0%. The difference of EFS was observed in patients receiving intermittent all-trans-retinoic acid (ATRA) administration or not in the maintenance therapy (88.9+/-10.5% vs 62.5+/-13.6%) (P<0.05).</p><p><b>CONCLUSIONS</b>The AML-XH-99-M3 protocol for the treatment of APL produced a higher CR rate and higher EFS, DFS and OS rates in children. Intermittent administration of ATRA in the maintenance therapy can improve EFS rate.</p>
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1
Base de dados:
WPRIM
Assunto principal:
Tretinoína
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Leucemia Promielocítica Aguda
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Protocolos de Quimioterapia Combinada Antineoplásica
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Daunorrubicina
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Mortalidade
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Citarabina
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Usos Terapêuticos
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Tratamento Farmacológico
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Etoposídeo
Tipo de estudo:
Guideline
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Prognostic_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2008
Tipo de documento:
Article