Studies on absorption kinetics of scopoletin in rat stomachs and intestines / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1890-1894, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-252201
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study absorption kinetics of scopoletin in rat stomachs and intestines.</p><p><b>METHOD</b>Rats was cannulated for in situ recirculation. UV and HPLC methods were used to determine the concentrations of phenolsulfonphthalein and scopoletin, respectively.</p><p><b>RESULT</b>The absorption rates in rat stomachs at 2 h after administration was 76.31%; The absorption rates at colon, duodenum, ileum and jejunum were 46.25%, 40.54%, 38.21%, 32.77%, respectively. The absorption rate constant (Ka) at concentrations of 10.0144, 20.0288-40.0576 mg x L(-1) in intestine were 0.6434, 0.6137, 0.5970 h(-1), respectively. The Ka of scopoletin at pH of 6.0, 6.8 and 7.4 in intestine were 0.6217, 0.6033, 0.6137 h(-1), respectively.</p><p><b>CONCLUSION</b>The concentrations and pH values of scopoletin solution had no distinctive effect on the absorption kinetics. The absorption of scopoletin was a first-order process with passive diffusion mechanism. Scopoletin was well absorbed at stomachs and intestines in rats. Colon was the best absorption site of scopoletin, which suggest that a sustained-release preparation should be suitable for this compound.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Escopoletina
/
Espectrofotometria Ultravioleta
/
Estômago
/
Farmacocinética
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Absorção
/
Concentração de Íons de Hidrogênio
/
Absorção Intestinal
/
Intestinos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo