Expressions of bacterial 16S rRNA, IL-1beta, TNF-alpha and NGF in prostate tissues / 中华男科学杂志
National Journal of Andrology
; (12): 40-43, 2010.
Article
em Zh
| WPRIM
| ID: wpr-252876
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of bacteria in the etiology of chronic prostatitis.</p><p><b>METHODS</b>A total of 162 complete prostate specimens were obtained at autopsy from organ donors (aged 20 -38 yr) who died of non-prostatic diseases. Each of the samples from the peripheral zone of the prostate was divided into two parts, one for routine pathological examination and immunohistochemical studies of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha) and the nerve growth factor (NGF), and the other for PCR assay to detect the bacterial 16S rRNA gene (16S rDNA).</p><p><b>RESULTS</b>Fifty-one (31.5%) of the total specimens presented pathological changes of chronic prostatitis, of which 44 had mild focal stromal, 5 mild focal stromal and periglandular and 2 mild focal periglandular inflammation. The positive rate of 16S rDNA was 19.1% (31/162), 51.0% (26/51) in the chronic prostatitis and 4.5% (5/111) in the non-prostatitis specimens (chi2 = 29.783, P < 0.01). In the specimens with chronic prostatitis, the expressions of IL-1beta, TNF-alpha and NGF were significantly higher in the 16S rDNA positive than in the 16S rDNA negative group (P < 0.01).</p><p><b>CONCLUSION</b>Bacterial inflammation may play an important role in the etiology of chronic prostatitis.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Próstata
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Prostatite
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RNA Bacteriano
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RNA Ribossômico
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RNA Ribossômico 16S
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Doença Crônica
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Fator de Necrose Tumoral alfa
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Genes de RNAr
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Fator de Crescimento Neural
Limite:
Adult
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Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2010
Tipo de documento:
Article