Association between polymorphisms of HIF-1alpha, eNOS genes and individual variation in response to hypoxia training / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigated association between polymorphisms of HIF-1alpha, eNOS genes and individual variation in response to intermittent hypoxia training.</p><p><b>METHODS</b>41 health subjects, completed 4 weeks hypoxia training program (hypoxia exposure 10 h each day and 3 times hypoxia training each week), to observed the relationship between C1772T polymorphism in exon 12 of HIF-1alpha gene and 27-base pair(bp) variable number of tandem repeat polymorphism (VNTR), 4b/a, in intron 4 of eNOS gene and physiological parameters, such as VO2(max), Hb, RBC and SpaO2.</p><p><b>RESULTS</b>The results showed that the change of VO2(max) was higher in carriers with CT genotype than those of CC genotype, and the changes of Hb and RBC indicated higher tendency in the subjects carrying the CT genotype. Same results were observed in the changes of SpaO2 during period of exercising under hypoxic condition.</p><p><b>CONCLUSION</b>These findings suggested the possible associations between SNP/C1772T, VNTR/4ba and the individual variation in response to hypoxia training.</p>