Effect of ligustrazine and L-arginine on function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 134-137, 2007.
Article
em Zh
| WPRIM
| ID: wpr-253465
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the effect of ligustrazine (LGT) and L-arginine(L-Arg)on function of mitochondria in myocardium after myocardial ischemia/reperfusion injury (MI/RI).</p><p><b>METHODS</b>50 rabbits were randomly divided into five groups (n=10): Control group(A), MI/R group(B), MI/R + LGT group (C), MI/R+ L-Arg group (D), MI/R+ LGT + L-Arg group (E). The mitochondrial respiratory function, Ca2+ concentration ([Ca2+]m), malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were deter mined. Meanwhile, the contents of ATP and EC in the myocardial tissue were measured, respectively.</p><p><b>RESULTS</b>It was found that mitochondrial respiratory control rate (RCR), state 3 (ST3), SOD in C, D, E group were higher than those of B group, state 4 (ST4), [Ca2+]m, MDA were lower than those of B group, ATP and EC levels of myocardial tissue were higher than those in B group; and there were not significant differences between E and A group of above.</p><p><b>CONCLUSION</b>LGT and IL-Arg can improve function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits by decreasing oxygen free radical level and Ca" overload in the mitochondria.</p>
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Arginina
/
Pirazinas
/
Superóxido Dismutase
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Traumatismo por Reperfusão Miocárdica
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Cálcio
/
Malondialdeído
/
Metabolismo
/
Mitocôndrias Cardíacas
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2007
Tipo de documento:
Article