Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease?
Annals of the Academy of Medicine, Singapore
; : 191-196, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-253598
Biblioteca responsável:
WPRO
ABSTRACT
This review addresses the importance of psychoneuroimmunology (PNI) studies in understanding the role of acute and chronic psychological stressors on the immune system and development of coronary artery disease (CAD). Firstly, it illustrates how psychological stressors change endothelial function and lead to chemotaxis. Secondly, acute psychological stressors lead to leukocytosis, increased natural killer cell cytotoxicity and reduced proliferative response to mitogens while chronic psychological stressors may lead to adverse health effects. This will result in changes in cardiovascular function and development of CAD. Thirdly, acute and chronic psychological stressors will increase haemostatic factors and acute phase proteins, possibly leading to thrombus formation and myocardial infarction. The evidence for the effects of acute and chronic psychological stress on the onset and progression of CAD is consistent and convincing. This paper also highlights potential research areas and implications of early detection of immunological changes and cardiovascular risk in people under high psychological stress.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psicologia
/
Estresse Psicológico
/
Trombose
/
Doença da Artéria Coronariana
/
Proteínas de Fase Aguda
/
Alergia e Imunologia
/
Inflamação
/
Infarto do Miocárdio
Tipo de estudo:
Estudo de rastreamento
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2010
Tipo de documento:
Artigo