Outcomes of locally advanced prostate cancer: a single institution study of 209 patients in Japan / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 555-561, 2006.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-253803
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the outcomes for Asian populations with locally advanced/clinical stage III prostate cancer (PCa) treated with currently prevailing modalities.</p><p><b>METHODS</b>We reviewed the record of 209 patients with clinical stage III PCa, who were treated at Niigata Cancer Center Hospital between 1992 and 2003. Treatment options included hormone therapy-combined radical prostatectomy (RP+HT), hormone therapy-combined external beam irradiation (EBRT+HT) and primary hormone therapy (PHT).</p><p><b>RESULTS</b>The 5- and 10-year overall survival rates were 80.3% and 46.1% in all cohorts, respectively. The survival rates were 87.3% and 66.5% in the RP+HT group, 94.9% and 70.0% in the EBRT+HT group and 66.1% and 17.2% in the PHT group, respectively. A significant survival advantage was found in the EBRT+HT group compared with that in the PHT group (P < 0.0001). Also, the RP+HT group had better survival than the PHT group (P = 0.0107). The 5- and 10-year disease-specific survival rates for all cases were 92.5% and 80.0%, respectively. They were 93.8% and 71.4% in the RP+HT group, 96.6% and 93.6% in the EBRT+HT group and 88.6% and 62.3% in the PHT group, respectively. A survival advantage was found in the EBRT+HT group compared with the PHT group (P = 0.029). No significant difference was found in disease-specific survival between the EBRT+HT and RP+HT groups or between the RP+HT and PHT groups.</p><p><b>CONCLUSION</b>Although our findings indicate that radiotherapy plus HT has a survival advantage in this stage of PCa, we recommend therapies that take into account the patients'social and medical conditions for Asian men with clinical stage III PCa.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasia da Próstata
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prostatectomia
/
Neoplasias da Próstata
/
Radioterapia
/
Cirurgia Geral
/
Fatores de Tempo
/
Sangue
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Seguimentos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Artigo