Study on prognostic factors of chronic severe hepatitis / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze factors influencing prognosis and to develop a prognosis predicting model for patients with chronic severe hepatitis.</p><p><b>METHODS</b>Clinical data from 408 patients suffering from chronic severe hepatitis were divided into improved group and deteriorated group. The main clinical and laboratory variables were analyzed as predictive factors of prognosis with logistic regression analysis.</p><p><b>RESULTS</b>It was shown that age, sex, TBil, DBil, [Cl-], [Na+], WBC, MCV, PT, NH3, PTA, and BUN were different between the two groups with statistical significance (P < 0.05). The prognosis predicting model was P = 1/(1 + e(-y)), Y = -4.636 + 0.022X1 + 0.034X2 + 0.096X3 + 0.047X4 - 0.042X5, (X1-age, X2-TBil, X3-BUN, X4-MCV, X5-PTA).</p><p><b>CONCLUSION</b>Age, TBil, BUN, MCV and PTA are the independent risk factors related to prognosis of chronic severe hepatitis.</p>