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Comparision of high dose impulsion and low dose density chemotherapeutic regimens with paclitaxel plus cisplatin in advanced NSCLC / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 621-625, 2004.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-254270
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore high effective and low toxic chemotherapeutic regimens in the treatment of non-small-cell lung cancer (NSCLC).</p><p><b>METHODS</b>A total of 126 patients with advanced NSCLC (Stage III, IV) were randomly divided into two groups high dose impulsion chemotherapy group (HDIC group) and low dose density chemotherapy group (LDDC group) with 54 patients in HDIC group who received paclitaxel 135-175 mg/m2 on day 1, DDP 80-100 mg/m2 on day 1 and BCNU 125 mg given for brain metastasis on days 1-3 in a 4-6 weeks cycle. Seventy-two patients in LDDC group were given paclitaxel 60-80 mg/m2 on day 1, DDP 40-80 mg/m2 on day 1 repeated weekly and BCNU 125 mg given for brain metastasis with an interval of 2 weeks, in a 4-6 weeks cycle. Antiemetic agent and fluid were administered routinely in HDIC group whereas LDDC group was given antiemetic agent only.</p><p><b>RESULTS</b>Of 157 courses in HDIC group, an average of 2.9 courses per patient, CR 3, PR 23, SD 17 and PD 11 were observed. The effective remission rate was 48.1%, the median effective remission period was 4.5 months and the 1-year survival rate was 46.3%. Of 184 courses in LDDC group, an average of 2.6 courses per patient, CR 9, PR 30, SD 24 and PD 9 were observed. The effective remission rate was 54.2%, the median effective remission period was 6 months and the 1-year survival rate was 56.9%. The effective remission rate and the 1-year survival rate were higher in HDIC group than those in LDDC group, but there was no statistical difference between the two groups (P > 0.05). Severe toxicity was higher in HDIC group than in LDDC group. Two patients in HDIC group died of treatment-related complications (3.7%). Quality of life was better in LDDC group (70.8%) than in HDIC group (51.9%).</p><p><b>CONCLUSION</b>When comparing with high dose impulsion, low dose density regimen of paclitaxel plus cisplatin is more effective and better tolerated with improvement of quality of patients' life in the treatment of NSCLC due to its low dose and short interval duration.</p>
Assuntos
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Qualidade de Vida / Trombocitopenia / Indução de Remissão / Neoplasias Encefálicas / Esquema de Medicação / Carmustina / Protocolos de Quimioterapia Combinada Antineoplásica / Taxa de Sobrevida / Cisplatino Aspecto: Preferência do paciente Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2004 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Qualidade de Vida / Trombocitopenia / Indução de Remissão / Neoplasias Encefálicas / Esquema de Medicação / Carmustina / Protocolos de Quimioterapia Combinada Antineoplásica / Taxa de Sobrevida / Cisplatino Aspecto: Preferência do paciente Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2004 Tipo de documento: Artigo
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