Association of RNASET2 gene polymorphisms and haplotypes with Graves disease in Han Chinese population from coastal regions of Shandong / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 693-696, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-254534
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of RNASET2 gene polymorphisms and haplotypes with Graves disease (GD) in Han Chinese population from coastal regions of Shandong Province.</p><p><b>METHODS</b>A total of 471 GD patients and 472 controls were enrolled. Genotypes of single nucleotide polymorphisms (SNPs) in RNASET2 gene were determined with a Taqman probe on a Fluidigm EPl platform. Haplotypes and their frequencies were analyzed with a SHEsis online software.</p><p><b>RESULTS</b>There was a significant difference in allele frequencies of rs3777722, rs3777723 and rs9355610 between the GD patients and the controls (P=0.018; P=0.028; P=0.021).Allele frequencies of rs3777722 and rs9355610 were significantly lower in GD than in the controls (P=0.018, P=0.021). Haplotypes A-A-C-A and A-A-T-A were significantly more common in the control group compared with the GD group (P=0.046, OR=0.448, 95%CI0.200-1.006; P=0.049, OR=0.823, 95%CI0.678-0.999). The frequency of C-G-C-G haplotype was significantly higher in GD patient group than the control group (P=0.018).</p><p><b>CONCLUSION</b>RNASET2 gene polymorphisms and haplotypes are associated with GD in Han population from coastal areas of Shandong Province. rs3777722 and rs9355610 may contribute to the risk for GD.</p>
Texto completo:
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Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ribonucleases
/
Haplótipos
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Doença de Graves
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Proteínas Supressoras de Tumor
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Povo Asiático
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Frequência do Gene
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Genética
Limite:
Adolescente
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Adulto
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Idoso
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Idoso, 80 anos ou mais
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Criança
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2013
Tipo de documento:
Artigo