Effects of shenmai injection on lipid peroxidation in the lung following with ischemia/ reperfusion (I/R) injury of limb / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 13-15, 2006.
Article
em Zh
| WPRIM
| ID: wpr-254620
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To explore the effects of shenmai (Chinese transitional medicine) injection on lipid peroxidation in the lung following with ischemia/reperfusion (I/R) injury of limb.</p><p><b>METHODS</b>The models of I/R injury of limb were constructed in rabbits. Superoxide dismutase (SOD) and malondialdehyde (MDA) in into and out-flowing pulmonary blood (IPB, OPB) and lung tissue were measured, as well as the effects of shenmai injection were observed.</p><p><b>RESULTS</b>Compared with sham group, the activity of SOD in IPB, OPB and lung tissue were decreased, and the content of MDA was increased after 4 h ischemia followed by 4 h reperfusion. SOD increased and MDA decreased significantly by icy shenmai injection 30 min before reperfusion. The correlation analysis indicated that MDA was negatively correlated with SOD .</p><p><b>CONCLUSION</b>Oxygen free radicals metabolic confusion of lung occurred in the course of I/R, shenmai injection can alleviate lipid peroxidation, get rid of free radicals and inhibit the damage of lung.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Superóxido Dismutase
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Medicamentos de Ervas Chinesas
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Peroxidação de Lipídeos
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Traumatismo por Reperfusão
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Usos Terapêuticos
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Combinação de Medicamentos
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Tratamento Farmacológico
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Extremidades
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Isquemia
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2006
Tipo de documento:
Article