Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons / 中华病理学杂志
Chinese Journal of Pathology
; (12): 245-249, 2002.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-255398
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of selenium (Se) and iodine (I) and the compound of both on the proto-oncogenes c-fos and c-jun mRNA and their protein expression in the cultured rat hippocampus neurons.</p><p><b>METHODS</b>Using the technique of serum free hippocampus neuron culture, different doses of Se and I and Se + I compound were added into the medium. The expression of the mRNA of c-fos, c-jun in hippocampus neurons cultured for 1, 3, 5, 7 and 10 d were studied using both in situ hybridization and SABC immunohistochemical technique.</p><p><b>RESULTS</b>Both Se and I could enhance the expression of c-fos, c-jun mRNA and their proteins, especially the combination of I and Se able to give a remarkable effect on c-jun mRNA expression.</p><p><b>CONCLUSIONS</b>Se and I may effect the expression of both c-fos and c-jun mRNA, especially the c-jun mRNA and its protein of hippocampus neurons, and thus may effect the differentiation and development of neurons.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Selênio
/
RNA Mensageiro
/
Proteínas Proto-Oncogênicas c-jun
/
Proteínas Proto-Oncogênicas c-fos
/
Proteínas de Ligação a DNA
/
Hipocampo
/
Iodo
/
Metabolismo
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2002
Tipo de documento:
Artigo