Efficacy of short-term and intensive chemotherapy for the treatment of childhood and adolescent B cell non-Hodgkin's lymphoma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 581-584, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-255839
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To evaluate the efficacy and toxicity of the B-NHL-BFM-90 protocol in the treatment of Chinese childhood and adolescent B-cell non-Hodgkin's lymphomas (B-NHL).</p><p><b>METHODS</b>Forty-two untreated childhood and adolescent B-NHL were enrolled in the present study. Of them 18 cases were Burkitt's lymphoma, 16 diffuse large B cell lymphoma and 8 anaplastic lymphoma. There were 10 cases in stage II and 32 in stage III/IV. The patients were grouped by risk factors into low, medium and high risk groups. All patients were treated with the B-NHL-BFM 90 (Berlin-Frankfurt- Münster) protocol. The low risk group received A, B courses for 4 cycles, the medium risk group AA, BB courses for 6 cycles, and the high risk group AA, BB, CC courses for 6 cycles.</p><p><b>RESULTS</b>Complete remission (CR) was obtained in 37 patients (88%), and partial remission (PR) in 5 (12%). Of the 5 PR patients, I received autologous hematopoietic stem cell transplantation, 3 received radiotherapy for residual disease and 1 just under watching. Major toxicity was myelosuppression and mucositis, especially in AA, BB and CC cycles, but was tolerant and manageable. Median follow-up was 20 (4 - 89) months. Kaplan-Meier method was used to analyse survival data. Two year event free survival (EFS) for all patients was 86. 24%, being 100% for stage II and 80.95% for stage III/IV.</p><p><b>CONCLUSION</b>Short term and intensive chemotherapy can improves the efficacy and survival rate of childhood and adolescent B-NHL, especially for advanced stage patients.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Estudos de Viabilidade
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Estudos Retrospectivos
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Seguimentos
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Linfoma de Células B
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Resultado do Tratamento
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Tratamento Farmacológico
Tipo de estudo:
Guia de prática clínica
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Adolescente
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Adulto
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Criança
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Criança, pré-escolar
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Feminino
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Humanos
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Lactente
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo