Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea
Immune Network
; : 311-315, 2016.
Article
em En
| WPRIM
| ID: wpr-25613
Biblioteca responsável:
WPRO
ABSTRACT
A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Orthomyxoviridae
/
Óvulo
/
Suínos
/
Vacinas contra Influenza
/
Linhagem Celular
/
Agricultura
/
Ovos
/
Influenza Humana
/
Pandemias
/
Soroconversão
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2016
Tipo de documento:
Article