Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 248-251, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-256378
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Puerarin on L-type calcium channel in isolated rat ventricular myocytes.</p><p><b>METHOD</b>The cardiac ventricular myocytes were isolated enzymatically by Langendorff perfusion techniques at constant flow rate. Whole-cell recording of patch-clamp techniques was used to observe the current of L-type calcium channel.</p><p><b>RESULT</b>Puerarin 2.4 mmol x L(-1) could inhibit the current of L-type calcium channel of rat ventricular myocytes and this inhibition was time-dependent. Purerarin elevated the current-voltage (I-V) curve of calcium current.</p><p><b>CONCLUSION</b>Puerarin can inhibit L-type calcium current of rat ventricular myocytes. Which implies that puerarin takes part in anti-myocardial ischemia and anti-arrhythmics partly due to the inhibition of L-type calcium channel.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Separação Celular
/
Química
/
Ratos Sprague-Dawley
/
Técnicas de Patch-Clamp
/
Canais de Cálcio Tipo L
/
Pueraria
/
Biologia Celular
/
Miócitos Cardíacos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2004
Tipo de documento:
Artigo