A research of endothelial cell-targeted therapy for cure of hypertrophic scar / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 254-257, 2003.
Article
em Zh
| WPRIM
| ID: wpr-256438
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility of endothelial cell-targeted therapy to cure post-burn hypertrophic scar.</p><p><b>METHODS</b>A hypertrophic scar animal model was made. Intralesional injecting of VEGF monoclonal antibody was performed for three weeks. The changes of scar in volume and morphology were observed.</p><p><b>RESULTS</b>1. The volume of scar decreased. 2. The number of the capillary, the amount of collagen I and collagen III decreased. 3. Transmission electron microscope examinations demonstrated many dead or apoptotic fibroblasts and endothelial cells. Fibrocytes were seen relatively common.</p><p><b>CONCLUSION</b>VEGF induces the growth and development of hypertrophic scar in that it induces excessive and uncontrollable angiogenesis, which favors excessive collagen synthesis. Endothelial cell-targeted therapy may be a promising method to cure post-burn hypertrophic scar.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Terapêutica
/
Queimaduras
/
Estudos de Viabilidade
/
Cicatriz Hipertrófica
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Apoptose
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Colágeno Tipo I
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Colágeno Tipo III
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Células Endoteliais
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Fator A de Crescimento do Endotélio Vascular
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Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2003
Tipo de documento:
Article