The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells / 中华预防医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the role of caspase-8 in vitamin E succinate (VES)-induced apoptosis in human gastric carcinoma cells.</p><p><b>METHODS</b>The expression and activity of caspase-8 were measured by the Western Blot method with fluorescence and DAPI staining.</p><p><b>RESULTS</b>VES treatment induced the expression and activity of caspase-8 in a dose-dependent manner; the apoptosis ratio induced by VES was significantly decreased in SGC-7901 cells treated with caspase-8 inhibitor.</p><p><b>CONCLUSION</b>Caspase-8 plays an important role in SGC-7901 cell apoptosis induced by VES.</p>