Influence of recombinant human growth hormone on body fluid compartments and water-sodium retention in severe burn patients / 中华烧伤杂志
Chinese Journal of Burns
; (6): 418-420, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-257466
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of recombinant human growth hormone (rhGH) on body fluid compartments and water-sodium retention in severe burn patients.</p><p><b>METHODS</b>Thirty adult patients with severe burn were divided into treatment (T) and control (C) groups by block randomized design. Patients in both groups were subcutaneously injected with same amount of rhGH (12 IU/d) or isotonic saline during 7 - 21 post burn day (PBD). The total body water (TBW), intracellular water (ICW), extracellular water (ECW) were measured by bioelectrical impedance analysis (BIA) on 7, 14, 21 PBD. The 24 h urinary output of Na+ was determined by ion selective electrode method (ISE).</p><p><b>RESULTS</b>There were no significant difference in levels of TBW, ICW, ECW and 24 h urinary output of Na+ between two groups on 7, 14, 21 PBD (P > 0.05). No difference in results was found between groups at different time points (P > 0.05). After the data were analyzed, the level of TBW (36 +/- 6 L), ICW (21 +/- 4 L) on 21 PBD were evidently lower than those on 7 PBD (38 +/- 6 L, 23 +/- 7 L, P < 0.01).</p><p><b>CONCLUSION</b>The level of ICW and TBW in severe burn patients decreased along with the time. Proper dosage of rhGH has no significant effect on body fluid compartments and water-sodium retention.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sódio
/
Terapêutica
/
Compartimentos de Líquidos Corporais
/
Água Corporal
/
Queimaduras
/
Impedância Elétrica
/
Hormônio do Crescimento Humano
/
Usos Terapêuticos
/
Edema
/
Espaço Extracelular
Tipo de estudo:
Ensaio clínico controlado
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2008
Tipo de documento:
Artigo