Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 687-690, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-258889
Biblioteca responsável:
WPRO
ABSTRACT
To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on perinatally exposed rat offspring, A1254 was administered by gavage from gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral development analysis revealed delayed appearance of the righting reflex, negative geotaxis, and cliff drop test responses in A1254 exposed group. Developmental A1254 exposure also caused oxidative stress in the brain of PND 22 offspring via reductions in the activity of SOD and GSH-Px, and by promoting a rise in the levels of NO and NOS.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Superóxido Dismutase
/
Envelhecimento
/
Peroxidação de Lipídeos
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Distribuição Aleatória
/
Córtex Cerebral
/
Estresse Oxidativo
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Óxido Nítrico Sintase
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Toxicidade
/
Glutationa Peroxidase
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2015
Tipo de documento:
Artigo