Effect of neuronal differentiation induced by nerve growth factor on the tolerance-dosage of ultraviolet radiation of PC12 cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 24-26, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-259083
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of neuronal differentiation induced by nerve growth factor (NGF) on the tolerance-dosage of ultraviolet radiation of PC12 Cells.</p><p><b>METHODS</b>Neuron-differentiated PC12 cells and untreated PC12 cells were exposed to different ultraviolet radiation dosage of 10, 30, 60, 80, 100, and 200 mJ/cm2. Cell survival rates were determined by MTT assay.</p><p><b>RESULTS</b>Neuron-differentiated PC12 cells had increased tolerance dose to ultraviolet radiation with noticeable apoptosis at the radiation dose of 100 mJ/cm2 in contrast to 30 mJ/cm2 for normal PC12 cells.</p><p><b>CONCLUSION</b>Neuronal differentiation exerts the effect of increasing the tolerance dose of PC12 cells to ultraviolet radiation.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Efeitos da Radiação
/
Raios Ultravioleta
/
Diferenciação Celular
/
Transformação Celular Neoplásica
/
Células PC12
/
Fator de Crescimento Neural
/
Biologia Celular
/
Relação Dose-Resposta à Radiação
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2009
Tipo de documento:
Artigo