Effect of endogenous histamine on ischemic preconditioning induced cerebral ischemic tolerance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 579-583, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-259263
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of endogenous histamine on ischemic preconditioning induced cerebral ischemic tolerance in rats.</p><p><b>METHODS</b>Wild-type (WT) mice and histidine decarboxylase knock-out (HDC-KO) mice were preconditioned by bilateral carotid artery occlusion (BCCAO) for 6, 10,or 14 min and reperfused for 48 h,then subjected to permanent BCCAO and the survival time of WT and HDC-KO mice subjected to permanent BCCAO was observed. Histamine levels in the hypothalamus, hippocampus, striatum and cortex at 0.5 h,5 h or 48 h after 10 min BCCAO were determined with high-performance liquid chromatography.</p><p><b>RESULT</b>Ten minutes ischemic preconditioning significantly prolonged the survival time of WT mice subjected to permanent BCCAO. However,in HDC-KO mice, the ischemic tolerance was not induced with 10 min preconditioning. The histamine levels at 0.5 h or 48 h increased after 10 min preconditioning, but not at 5 h.</p><p><b>CONCLUSION</b>Endogenous histamine in brain may be an essential mediator in ischemic preconditioning induced cerebral ischemic tolerance.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Traumatismo por Reperfusão
/
Histamina
/
Distribuição Aleatória
/
Isquemia Encefálica
/
Camundongos Knockout
/
Precondicionamento Isquêmico
/
Metabolismo
/
Camundongos Endogâmicos C57BL
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2009
Tipo de documento:
Artigo