Effect of three penetration enhancers on corneal permeability of mangiferin in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3131-3135, 2010.
Article
em Zh
| WPRIM
| ID: wpr-260738
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of labrasol, solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.</p><p><b>METHOD</b>The effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.</p><p><b>RESULT</b>The apparent Papp enhancements were increased 1.80, 3.27, 3.41 and 4.76-folds with Lab at 1.0%, 1.5%, 2.0% and 3.0% (P < 0.01), respectively. The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4% (P < 0.01), respectively, but reduced with 0.010%-0.03% Trans.</p><p><b>CONCLUSION</b>The Papp value of mangiferin is significantly enhanced by 1.0%-3.0% Lab, 0.2% and 0.4% Sol, however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Compostos Orgânicos
/
Permeabilidade
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Polietilenoglicóis
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Ácidos Esteáricos
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Técnicas In Vitro
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Portadores de Fármacos
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Farmacocinética
/
Extratos Vegetais
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Química
/
Córnea
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Article