Preparation and properties of calcium polyphosphate-based composite scaffold for bone tissue engineering / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1047-1050, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-260941
Biblioteca responsável:
WPRO
ABSTRACT
Calcium polyphosphate (CPP) is a new type of degradable material for bone repair, yet it is fragile and is not so controllable in regard to degradation. For increasing biological activity and close proximity to natural bone structure, in this experiment, we chose chitosan (CS) and its derivative carboxymethyl chitosan (CMC) as the extracellular matrix structure for the organic phase. Aldehyde sodium alginate (ADA) was used as natural cross-linker. The binary (CPP/CMC) and ternary (CPP/CMC/CS) composite scaffolds were prepared by the "multiple composite-cross-linking method". The degradation laws of the two materials were investigated through the weight loss of scaffolds, the pH value of degradation solution, the compressive strength and the surface morphology characterization. The results showed that the composite scaffolds had good interface and the compressive strength increased greatly, but the organic phase of dual-phase composite scaffolds degraded quickly, while degradation controllability and mechanical properties of ternary composite scaffold were significantly improved. All the above findings show that the method of ternary complex scaffold preparation is useful for the design and preparation of bone tissue engineering materials.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Materiais Biocompatíveis
/
Cimentos Ósseos
/
Fosfatos de Cálcio
/
Química
/
Implantes Absorvíveis
/
Engenharia Tecidual
/
Quitosana
/
Alicerces Teciduais
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2010
Tipo de documento:
Artigo