Clinical and experimental study of two cases of myelodysplastic syndrome with t(3; 5) (q25; q34) translocation / 中华血液学杂志
Chinese Journal of Hematology
; (12): 304-306, 2002.
Article
em En
| WPRIM
| ID: wpr-261405
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To report two myelodysplatic syndromes (MDS) patients with t(3; 5) (q25; q34).</p><p><b>METHODS</b>Chromosome specimens were prepared by short-term culture of bone marrow cells. Karyotype analysis was performed by R banding technique, chromosome painting (fluorescence in situ hybridization, FISH) by using whole chromosome 3 and 5 probes in case 1.</p><p><b>RESULTS</b>The clinical and hematological findings were compatible with diagnosis of MDS. Karyotype analysis showed that both patients had identical t(3; 5) (q25; q34) translocation. A reciprocal translocation between chromosomes 3q and 5q was proved by FISH in one patient.</p><p><b>CONCLUSIONS</b>t(3; 5) translocation is a rare chromosome abnormality specifically associated with MDS and frequently displays trilineage dysplasia. Chromosome painting technique is a reliable tool for detecting this translocation.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Translocação Genética
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Síndromes Mielodisplásicas
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Cromossomos Humanos Par 3
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Cromossomos Humanos Par 5
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Leucócitos Mononucleares
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Antígenos CD
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Classificação
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Hibridização in Situ Fluorescente
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Alergia e Imunologia
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Genética
Limite:
Adolescent
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Adult
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Humans
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Male
Idioma:
En
Revista:
Chinese Journal of Hematology
Ano de publicação:
2002
Tipo de documento:
Article