Preparation of multivariant-phospholipid complex of Ginkgo biloba extract / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare Ginkgo biloba extract multivariant-phospholipid complex(MGBP) and improve the vitro dissolution of ginkgo total flavonoids by adding another water-soluble carrier in phospholipid complex.</p><p><b>METHOD</b>MGBP was prepared using solvent evaporation method with Poloxamer-188 as the carrier and the multivariant complex was analyzed by DSC and X-diffraction technique. The physicochemical properties of the MGBP we also studied, including apparent oil-water distribution coefficients in different pH aqueous solution and its release in vitro.</p><p><b>RESULT</b>The in vitro dissolution of ginkgo total flavonoids was significantly increased while the apparent oil-water distribution coefficient was improved after been made into multivariant-phospholipid complex.</p><p><b>CONCLUSION</b>The preparation technology of MGBP is simple and economic. MGBP can significantly increase the vitro dissolution of ginkgo total flavonoids and improve oil-water distribution coefficients, which can be the reference for the bioavailability in vivo in the further researches.</p>