Preparation and pharmacodynamic evaluation of diammonium glycyrrhizinate-loaded chitosan nanoparticles / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2138-2141, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-262206
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare the diammonium glycyrrhizinate-loaded chitosan nanoparticles (DG-CS NPs), and evaluate its pharmaceutical properties and pharmacodynamic effects on ulcerative colitis (UC).</p><p><b>METHOD</b>DG-CS NPs were prepared by spray drying method and optimized by orthogonal design. The morphology, size and in vitro release of DG-CS NPs were investigated. The therapeutic effects of DG-CS NPs on UC mice induced by dextran sulfate were evaluated preliminarily through disease active index method.</p><p><b>RESULT</b>The size of DG-CS NPs with loading capacity about (51.25 +/- 1.75)% was in the range of 300-600 nm. The release of DG-CS NPs was associated with environmental pH value and displayed significant therapeutic and preventive effects on UC.</p><p><b>CONCLUSION</b>DG-CS NPs prepared by spray drying method showed efficacy on UC mice.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Colite Ulcerativa
/
Química
/
Sulfato de Dextrana
/
Ácido Glicirrízico
/
Usos Terapêuticos
/
Quitosana
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
/
Toxicidade
/
Nanopartículas
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo