In vitro activity of gallic acid against Candida albicans biofilms / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of gallic acid against Candida albicans biofilms in vitro.</p><p><b>METHOD</b>XTT reduction assay was performed to determine the effect of gallic acid on C. albicans biofilms and its adherence, and microscopic examination was conducted to assess the effect of gallic acid on morphogenesis of C. albicans biofilms; and cytotoxic assay was used to measure the adverse effects of gallic acid.</p><p><b>RESULT</b>SMIC50, SMIC50 of gallic acid against C. albicans biofilms were 500, 1000 mg x L(-1), respectively; 100 mg x L(-1) and 1000 mg x L(-1) of gallic acid could inhibit the initial adherence and filamentous growth, and the agent showed poor cytotoxic activity.</p><p><b>CONCLUSION</b>gallic acid displayed potent activity against C. albicans biofilm.</p>