Assessment of coagulation with 6% hydroxyethyl starch 130/0.4 in cesarean section / 대한마취과학회지
Korean Journal of Anesthesiology
; : 337-342, 2012.
Article
em En
| WPRIM
| ID: wpr-26357
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Third-generation hydroxyethyl starch (HES) solutions have been developed to minimize negative effects on hemostasis. In normal pregnancy, the coagulation activity increases, reaching a maximum around term. This study examined the effects of hemodilution with HES 130/0.4 (6%) on blood coagulation in parturients in vivo and in vitro. METHODS: Forty parturients scheduled for cesarean sections were assigned randomly to receive either 500 or 1,000 ml of HES 130/0.4 (6%). Rotation thromboelastometry (ROTEM(R)) measurements were performed before and after administering HES 130/0.4 (6%). In addition, blood samples obtained from 20 randomly selected parturients were diluted 10% to 40% using HES 130/0.4 (6%), and ROTEM(R) measurements were performed before and after dilution. The changes from baseline and the effects of dilution were analyzed by ROTEM(R) parameters. RESULTS: Infusions of 500 or 1,000 ml of HES 130/0.4 (6%) in the parturients altered the clot formation time, alpha angle, and maximal clot firmness, although all remained within normal ranges. HES 130/0.4 (6%) affected in vitro blood coagulation in parturients' blood containing 10, 20, 30, and 40% HES. The clotting time was prolonged at each dilution percentage, but remained within the normal range. Other parameters showed an impairment of the coagulation system. CONCLUSIONS: Blood coagulation in parturients may be compromised at high dilution ratios of HES 130/0.4 (6%) to blood. Nevertheless, the infusion of 1,000 ml of HES 130/0.4 (6%) in normal parturients did not significantly affect blood coagulation.
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Base de dados:
WPRIM
Assunto principal:
Valores de Referência
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Coagulação Sanguínea
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Cesárea
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Derivados de Hidroxietil Amido
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Hemodiluição
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Hemostasia
Limite:
Pregnancy
Idioma:
En
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2012
Tipo de documento:
Article